Neglecting or refusing to obey; omitting to do what is commanded, or doing what is prohibited; refractory; not observant of duty or rules prescribed by authority; as children disobedient to parents; citizens disobedient to the laws. I was not disobedient to the heavenly vision. Acis 26:79.

Not yielding to exciting force or power. Medicines used unnecessarily contribute to shorten life, by sooner rendering peculiar parts of the system disobedient to stimuli.