Literally, an undue or unnatural temper, or disproportionate mixture of parts. Hence,

Disease; malady; indisposition; any morbid state of an animal body, or of any part of it; a state in which the animal economy is deranged or imperfectly carried on. It is used of the slighter disease, but not exclusively. In general, it is synonymous with disease, and is particularly applied to the diseases of brutes.

Want of due temperature, applied to climate; the literal sense of the word, but not now used. Countries under the tropic of a distemper uninhabitable.

Bad constitution of the mind; undue predominance of a passion or appetite.

Want of due balance of parts or opposite qualities and principles; as, the temper and distemper of an empire consist of contraries.

Ill humor of mind; depravity of inclination.

Political disorder; tumult.

Uneasiness; ill humor or bad temper. There is a sickness, which puts some of us in distemper.

In painting, the mixing of colors with something besides oil and water. When colors are mixed with size, whites of eggs, or other unctuous or glutinous matter, and not with oil, it is said to be done in distemper.

To disease; to disorder; to derange the functions of the body or mind.

To disturb; to ruffle.

To deprive of temper or moderation.

To make disaffected, ill humored or malignant. This verb is seldom used, except in the participles.