Hopelessness; a hopeless state; a destitution of hope or expectation. We are perplexed, but not in despair. 2 Corinthians 4:8. All safety in despair of safety placed.

That which causes despair; that of which there is no hope. The mere despair of surgery, he cures.

Loss of hope in the mercy of God.

To be without hope; to hive up all hope or expectation; followed by of. We despaired even of life. 2 Corinthians 1:8. Never despair of Gods blessings here, or of his reward hereafter.